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I have read with great interest the article ‘Fracture safety of double-porous hydroxyapatite biomaterials’, authored by Dejaco et al.1 There is a signal that more is about to follow in this research, since the authors have adopted a unique quantitative engineering principle to assess the fracture safety of double-porous hydroxyapatite-based biomaterials. The authors have used microcomputed tomography (micro-CT) of macropores and voxel-specific microporosities at submillimetre scales. During the last few years, several modelling approaches have been developed for predicting the mechanical behaviour of such biomaterials and even natural tissues, such as bone, but they have almost failed to...

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