Table 5

A summary of weakly supervised nuclei segmentation methods.

Ref.DatasetMethodsPre-ProcessingPost-Processing
[106]MoNuSeg, TNBCResNet-50 backbone segmentation net supervised by auxiliary PseudoEdgeNetLabel assignment -Voronoi and distance transformThresholding
[74]Lung Cancer Dataset, Kumar DatasetSemi-supervised nuclei detection followed by weakly supervised segmentation (using ResNet backbone U-Net)Color normalization, patch extraction, data augmentation, ResNet-34 encoder pretrained, Voronoi and K-means cluster labeling-
[75]Lung Cancer Dataset, Kumar DatasetUncertainty prediction from Bayesian CNN followed by normal CNN trained with partial points and mask labelsColor normalization, patch extraction, data augmentation-
[95]MoNuSeg, TNBCCoarse segmentation using self supervision followed by fine segmentation with contour sensitive constraintPoint distance map and Voronoi edge distance map generation-
[54]MoNuSeg, CPM-17Co-trained U-Net based Segmentation-Colorization NetworkPatch extraction, data augmentation, H-component extraction, Voronoi and K-means cluster labeling-
[36]MoNuSegGAN based nuclei centroid detection followed by peak region backpropagationStain normalization, patch extractionGraph cuts
[58]Kumar, TNBC, MoNuSegConditional SinGAN based training data augmentation from selected patches followed by Mask RCNN for semi-supervised segementationPatch extraction, data augmentation-

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