Table I Our analytical framework applied... | Emerald Publishing

Table I

Our analytical framework applied to the ENABLE case

	ENABLE		Specific drug programs
1. Temporality issues/time constraints	Private part: Actor: new programs (and their owners) joining, termination of programs, personnel turnover, exposure to new contacts Resource: lack of development programs, Drug Discovery Platform underused Activity: creation of routines by CMO/PMC for milestone declaration, go/no-go decisions, new hit-owners routines and fast time expectations on activities	Public part: Actor: new programs joining, termination of programs (Lower personnel turnover), exposure to new contacts Resource: changing resource constellation, bottlenecks, required timely and effective use of resources Activity: creation of routines by CMO/PMC for milestone declaration and go/no-go decisions, expectations of highest speed for drug discovery hub activities, allocation and re-allocation of resources depending on periodic volumes	Private part: Actor: development of trust, alignment of goals, stress for some Resource: pivotal effective use of resources, other funding running out fast (SMEs) Activity: take longer time than expected, pushing to get times respected by public partners, preparation for PMC meetings, need high coordination and follow ENABLE pacing	Public part: Actor: development of trust and commitment harder to achieve, alignment of goals, stress for most Resource: highly specialized resources, capacity constraints when time pressure, bottleneck for delivery of data Activity: new experiment procedures, short timelines, no time for writing publications and general learning
2. Coordination tools for the time issues	Private part: Actor: meetings and specified roles Resource: PMC timeline request, budgets and periodic resource allocation to various partners Activity: milestones, indicative timelines for development stages and termination of entire project	Public part: Actor: meetings and specified roles Resource: PMC timeline request, budgets and periodic resource allocation to various partners Activity: milestones, indicative timelines for development stages and termination of the entire project	Private part: Actor: meetings and specified roles Resource: suggested timelines and strict criteria on molecule qualities for program progress Activity: flowcharts, timelines and termination decision of a program, role-based coordination	Public part: Actor: meetings and specified roles Resource: suggested timelines and strict criteria on molecule qualities for program progress Activity: flowcharts, timelines and termination decision of a program, roles-based coordination
3. Consequences for the parties	Private part: Actor: turnover of personnel and of organizations require to rebuild trust constantly. New contacts Resource: fair possibility of reaching overall project goals in terms of molecules. New resource constellations Activity: highly coordinated routines, but possible delays when new partner enter and need to learn ENABLE process. New activity patterns	Public part: Actor: need to rebuilt trust with new private counterparts. New contacts Resource: bottlenecks during the project for all programs, funding will be stopped when ENABLE ends, and very limited academic publication output. New resource constellations Activity: learn how to perform new fast routines for efficient project management, no performance of academic research activities. New activity patterns	Private part: Actor: high turnover of personnel, relationships started outside ENABLE. New actor bonds Resource: longer (delayed) development time for key molecules, loss of competence for specific molecules. New resources ties Activity: coordination with public partners sometimes difficult due to different time-orientations. New activity links	Public part: Actor: some turnover of personnel and need to rebuild trust and commitment, relationships started outside ENABLE. New actor bonds Resource: loss of some competence, difficult recruitment, new technologies need new adaptions, adapted resources not transferrable to other programs. New resources ties Activity: some adaptions occurred, learnt new routines and how to work under time-pressure. New activity links

	ENABLE		Specific drug programs
1. Temporality issues/time constraints	Private part:Actor: new programs (and their owners) joining, termination of programs, personnel turnover, exposure to new contactsResource: lack of development programs, Drug Discovery Platform underusedActivity: creation of routines by CMO/PMC for milestone declaration, go/no-go decisions, new hit-owners routines and fast time expectations on activities	Public part:Actor: new programs joining, termination of programs (Lower personnel turnover), exposure to new contactsResource: changing resource constellation, bottlenecks, required timely and effective use of resourcesActivity: creation of routines by CMO/PMC for milestone declaration and go/no-go decisions, expectations of highest speed for drug discovery hub activities, allocation and re-allocation of resources depending on periodic volumes	Private part:Actor: development of trust, alignment of goals, stress for someResource: pivotal effective use of resources, other funding running out fast (SMEs)Activity: take longer time than expected, pushing to get times respected by public partners, preparation for PMC meetings, need high coordination and follow ENABLE pacing	Public part:Actor: development of trust and commitment harder to achieve, alignment of goals, stress for mostResource: highly specialized resources, capacity constraints when time pressure, bottleneck for delivery of dataActivity: new experiment procedures, short timelines, no time for writing publications and general learning
2. Coordination tools for the time issues	Private part:Actor: meetings and specified rolesResource: PMC timeline request, budgets and periodic resource allocation to various partnersActivity: milestones, indicative timelines for development stages and termination of entire project	Public part:Actor: meetings and specified rolesResource: PMC timeline request, budgets and periodic resource allocation to various partnersActivity: milestones, indicative timelines for development stages and termination of the entire project	Private part:Actor: meetings and specified rolesResource: suggested timelines and strict criteria on molecule qualities for program progressActivity: flowcharts, timelines and termination decision of a program, role-based coordination	Public part:Actor: meetings and specified rolesResource: suggested timelines and strict criteria on molecule qualities for program progressActivity: flowcharts, timelines and termination decision of a program, roles-based coordination
3. Consequences for the parties	Private part:Actor: turnover of personnel and of organizations require to rebuild trust constantly. New contactsResource: fair possibility of reaching overall project goals in terms of molecules. New resource constellationsActivity: highly coordinated routines, but possible delays when new partner enter and need to learn ENABLE process. New activity patterns	Public part:Actor: need to rebuilt trust with new private counterparts. New contactsResource: bottlenecks during the project for all programs, funding will be stopped when ENABLE ends, and very limited academic publication output. New resource constellationsActivity: learn how to perform new fast routines for efficient project management, no performance of academic research activities. New activity patterns	Private part:Actor: high turnover of personnel, relationships started outside ENABLE. New actor bondsResource: longer (delayed) development time for key molecules, loss of competence for specific molecules. New resources tiesActivity: coordination with public partners sometimes difficult due to different time-orientations. New activity links	Public part:Actor: some turnover of personnel and need to rebuild trust and commitment, relationships started outside ENABLE. New actor bondsResource: loss of some competence, difficult recruitment, new technologies need new adaptions, adapted resources not transferrable to other programs. New resources tiesActivity: some adaptions occurred, learnt new routines and how to work under time-pressure. New activity links