Table 3

The impact of COVID-19 on patients with stroke

Reference##Delayed treatment (alteplase/thrombolysis/thrombectomy/consultation)Thrombotic/ blood and immune system complicationsNIHSS (stroke severity)mRS (disability)MortalityThe D-dimer levelsComorbiditiesARDSProlonged hospitalization
[17]*⋁*⋁*⋁*⋁     
[36] *⋁*⋁*⋁    
[18]***⋁***⋁   ***⋁   
[31]****⋁  ****⋁****⋁****⋁****⋁ 
[38]   ****⋁ ****⋁****⋁****⋁
[32]***⋁***⋁  ***⋁   
[39]   ****⋁ ****⋁ ****⋁
[37] #⋀    #⋀ 
[33]***±***± ***± ***± ***±
[19]*⋁*⋁       
[20]*⋁        
[21]*⋁        
[22]*⋁   *⋁    
[23]*⋁   *⋁    
[24]*⋁        
[25]*⋁        
[26]*⋁        
[27]*⋁        
[34]***⋁    ***⋁  
[28]*⋁        
[29]*⋁       *⋁
[30]*⋁        
[35]*⋁*⋁ *⋁*⋁   
Total (n)1486284534

Note(s): NIHSS National Institutes of Health Stroke Scale, mRS modified Rankin Scale, ARDS Acute Respiratory Distress Syndrome; ## One study reported ≥ one impact; Outcome significantly improved (no comparison group); *⋁ Outcome significantly worse compared to stroke patients without the diagnosis of COVID-19; ***⋁ Outcome significantly worse compared to stroke patients with the diagnosis of COVID-19; ***± Outcome combined results compared to stroke patients with the diagnosis of COVID-19; ****⋁ Outcome significantly worse compared to non-stroke patients with the diagnosis of COVID-19

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