Figure 3.
A line chart shows patch distribution across p value with nuclei and background regions separated by multiple threshold points.The horizontal axis shows p value from 0 to 1. The vertical axis shows patch distribution from 0 to about 0.016. Two smooth curves represent nuclei and background distributions. The nuclei distribution is higher at low p values and decreases after about 0.2. The background distribution is low at small p values and rises strongly after about 0.5, peaking near 0.85. Several thresholds are marked. T sub 1 appears near p value 0.05. T sub c prime appears slightly above 0.05. T hat is marked near p value 0.25. T sub o is marked at p value 0.4. Another T sub c appears near p value 0.75. L sub 12 connects a point near p value 0.4 to a point near the background peak.

Demonstration of the P-value distribution in a local patch where the bimodal assumption holds. The auxiliary lines to calculate the adapted threshold T^ are also depicted

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