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Global environmental and social threats challenge humans’ well-being and the survival of posterity. Industry 4.0 (I4.0) transformed the industry sector, enabling process automation and scalability, increasing manufacturers’ productivity, efficiency, and profitability, and supporting manufacturing innovation and firms’ competitive advantage. Despite this, the I4.0 paradigm, as currently conceived, does not fit for purpose in the context of the climate crisis and planetary emergency, nor does it address deep social tensions.

Therefore, a new revolution focusing on human and environmental needs is strongly required to address society’s economic and social problems. Combining digitalization and social purposes may address local, national, and international issues by involving a human-centered perspective in traditional business-oriented entrepreneurship.

Depending on the above, this chapter provides an in-depth understanding of Digital Entrepreneurship (DE), Digital Social Entrepreneurship (DSE), and how entrepreneurs may employ digital technologies to reach business and social aims.

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