I would like to thank many colleagues for their insights and suggestions, especially S. Zha (Columbia University), S. Xie (Peking University), Y. Zhang (Harvard Medical School). Q. P.-H.’s research group is supported by the European Union’s Horizon 2020 research and innovation programme (ATAC, No 101003650), the European Research Council, CIMED, the Swedish Research Council, the Swedish Cancer Society, the Knut and Alice Wallenberg Foundation and funds from the Karolinska Institutet.

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