This work was supported by Education Science Project of Guangdong province: ‘Design and practice of flipped classroom teaching based on SPOC’ (2017); Teaching Reform Project of Guangdong province: ‘Design and practice of online open course’s construction path’ ( 2016); Education reform and practical project of Guangdong province (No. 38030105); Scientific Research Project of Shantou University (STF14003); the Institute of Guangdong and Taiwan of Shantou University for their financial support; and by the Ministry of Science of Technology, Taiwan (MOST 106-2511-S-003-029-MY3).

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