School-university partnerships are enhanced by synergistic relationships. Positive outcomes increase when partners work across disciplines, focus on cultural competencies, and expand from local to global engagement. This chapter offers an overview of the Bradley Professional Development Schools (PDS) Partnership, a description of the Comprehensive Integrated Services Model, and a summary of current thinking about synergy and cultural competencies in relation to school–university partnerships. Through descriptions of various multidisciplinary PDS projects and partnerships, the chapter explores concepts such as emergent realities, cross-cultural, intercultural or global competencies, empowering learning culture, and global awareness, demonstrating how an comprehensive integrated services model that is holistic in nature sustains school–university partnerships in multiple and creative ways across local and global environments.

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