Special educators make countless decisions regarding services for students with disabilities. The evidence-based practice movement in education encourages those decisions be informed by the best available evidence, professional judgment, and client values and context. In this chapter we argue that while evidence is the best basis for making decisions it is imperfect and uncertainty about the evidence-base for decisions will always exist. We outline three classes of evidence and the sources of uncertainty for each. Finally, we describe a framework for integrating these different sources of evidence as a means for increasing confidence in evidence-based decisions.

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