Design of textile scaffolds for tissue engineering: the use of biodegradable yarns

The emergence of tissue engineering has led to the development of three‐dimensional cellular scaffolds that reconstruct the tissue structure. Research into the use of biodegradable materials in scaffolds has grown; the aim is that when tissue growth is complete, the scaffold degrades completely. This research aims to design novel scaffolds and investigates biodegradable polylactide (PLA) yarns; in particular, poly(l‐lactide) (PLLA) yarns extruded in‐house. To study degradation and determine the effect on the biodegradable yarns/textiles, they were immersed in phosphate buffer solution (PBS, pH=7.4) for various durations at 37°C. Mechanical properties were evaluated on tensile testing rigs and they were observed, before and after the immersion period. Cells were then cultured (37°C, 5 per cent carbon dioxide in air) on the textiles for 1 week. As expected, after immersion, the yarns exhibit a decrease in elongation and tenacity. Initial results indicate that the yarn properties influence cell attachment and spreading.