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B-type natriuretic peptide-guided heart failure therapy

Article Type: Reviews of effectiveness From: Clinical Governance: An International Journal, Volume 15, Issue 3

Porapakkham, P., Porapakkham, P., Zimmet, H., Billah, B. and Krum, H,B-type natriuretic peptide-guided heart failure therapy,Archives of Internal Medicine,2010,Vol. 170,pp. 507-514

This review compared the effect of B-type natriuretic peptide (BNP)-guided drug therapy with usual care in patients with chronic heart failure. The authors concluded that BNP-guided therapy reduced all-cause mortality, especially in patients younger than 75 years. This was a reasonably well-conducted review, but the uncertain quality of included trials and concerns regarding generalisability warrant some cautious interpretation.

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