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Argues that strong social analysis can make a large contribution to understanding and fighting HIV/AIDS plus other infective diseases. Contends a global perspective is necessary to rethink our approach to infections as, globally, the virus seems to be strengthening, generally. Describes, through case studies, the transition of HIV outbreaks in South Africa, Eastern Europe, Russia, and Indonesia. Makes the case that HIV/AIDS is deeply tied up in fundamental structure and processes.

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