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This article outlines the experience of the first 260 Sure Start Local Programmes of developing interagency partnerships in their areas. It draws on quantitative and qualitative data collected between 2000‐2005 by the implementation module of the government‐commissioned National Evaluation of Sure Start. Following a résumé of the aims and design of the Sure Start Local Programme initiative, a description of the implementation module methodology and an overview of existing knowledge around inter‐agency collaboration, five factors are identified which impacted on the partnership‐building task. These comprise: the nature of partnership history; clarity of purpose; the extent of strategic commitment at the highest levels; trust among partners; and the characteristics of the national workforce. The article concludes by highlighting the continuing relevance of these issues to the new collaborations required by the UK government's Every Child Matters agenda, including the work of children's centres.

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