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Purpose

The purpose of this study is to systematically review the existing literature on the blood supply chain (BSC) from a network design perspective and highlight the research gaps in this area. Moreover, it also aims to pinpoint new research opportunities based on the recent innovative technologies for the BSC network design.

Design/methodology/approach

The study gives a comprehensive systematic review of the BSC network design studies until October 2021. This review was carried out in accordance with preferred reporting items for systematic reviews and meta-analyses (PRISMA). In the literature review, a total of 87 studies were analyzed under six main categories as model structure, application model, solution approach, problem type, the parties of the supply chain and innovative technologies.

Findings

The results of the study present the researchers’ tendencies and preferences when designing their BSC network models.

Research limitations/implications

The study presents a guide for researchers and practitioners on BSC from the point of view of network design and encourages adopting innovative technologies in their BSC network designs.

Originality/value

The study provides a comprehensive systematic review of related studies from the BSC network design perspective and explores research gaps in the collection and distribution processes. Furthermore, it addresses innovative research opportunities by using innovative technologies in the area of BSC network design.

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