A GENERAL MODEL OF SKELETAL MUSCULAR CONTRACTION: Part II: Introduction of the activation parameter and of nervous control Available to Purchase

We propose a comprehensive model of skeletal muscular contraction which connects the nervous control to the force generated by a given muscle during motion. We introduce a contractile proteins activation probability into A. F. Huxley's sliding filament theory, and we deduce this probability from the calcium turnover study described in part I. This modelization implies a discussion of the experimental determination and the published values of some constants concerning the calcium turnover (calcium concentration at rest, affinity constant for the specific sites of troponin C, rate constant for the release of calcium from the non‐specific sites of troponin C). We show that the troponin C non‐specific cationic sites are unambigously related to the calcium‐magnesium antagonism. We conclude with a numerical simulation for the medial gastrocnemius muscle of the cat.