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Agonistic antagonistic general system theory and praxis were born in the medical field, but may be defined now from an epistemological and biomathematical point of view, and are used in other fields. Reviews classical notions in General Systems Theory (GST), such as auto‐organization, hierarchy, the “middle way” etc. Discusses bilateral strategies, which are seemingly contradictory and the paradoxical unilateral strategy. Suggests that, if the efficient control of certain systems is at stake in such strategies, they ought to be scrutinized by the cybernetical community.

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