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Agonistic antagonistic system theory and praxis were born in the medical field, but may be defined now from an epistemological and biomathematical point of view. Describes new developments in agonistic antagonistic (AA) theory and presents new applications. These include new mathematical approaches that involve variable parameters and partial derivatives in models for the regulation of AA couples (MRAAC). Gives new biomedical applications and, in explanation, a mechanism called “pathological homeostasis” (PH) is introduced. Also provides details of therapeutical trials. Suggests systems science or cybernetical strategies which are likely to have a broad field of application, particularly among decision makers in general.

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