Frank H. George Research Award winning paper Cancer self‐remission and tumour instability – a cybernetic analysis Towards a fresh paradigm for cancer treatment

Aims to investigate the causative factors and clinical applicability of spontaneous regression of malignant tumours without treatment, a really paradoxical phenomenon with many therapeutic potentialities. Analyses past cases to find that the commonest cause is a preceding episode of high fever‐induced thermal fluctuation which produces fluctuation of biochemical/immunological parameters. Using Prigogine‐Glansdorff‐Langevin stability theory and biocybernetic principles, develops the theoretical foundation of a tumour’s self‐control, homeostasis and regression induced by thermal, radiation or oxygenation fluctuations. Derives a threshold condition of perturbations for producing regression. Presents some striking confirmation of such fluctuation‐induced regression in Ewing tumour, Clear cell cancer and Lewis lung carcinoma. Using experimental data on patients, elucidates a novel therapeutic approach of multi‐modal hyper‐fluctuation utilizing radiotherapeutic hyper‐fractionation, temperature and immune‐status.