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Labyrinth test psychophysiological experiment is elaborated to analyze possible mechanism of the probabilistic prognosis forming and realizing in the condition of essential information uncertainty. The dynamics of the probabilistic prognosis construction and improvement during multi‐stage labyrinth test solving is established. This dynamics is characterized by considerable changes of the subjective probabilities and membership function quantitative indices apparently used in the fuzzy logic of mental activity being applied in decision‐making processes realized in the condition of uncertainty. The possible link between probabilistic prognosis efficiency and some functional peculiarities of cortical hemisphere asymmetry has also been studied.