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Purpose

This study aims to investigate the evolution of research, development and innovation (R&D&I) projects addressing public health crises, analyzing the institutional and technological dynamics that shape project continuity, coordination and governance.

Design/methodology/approach

The study adopts a mixed-methods approach, combining a literature review, documentary analysis and relational network analysis to identify patterns of interaction among actors, technologies and thematic areas across different stages of R&D&I projects.

Findings

The findings indicate that public health crises function less as disruptive events and more as vectors of institutional consolidation. Technologies, particularly artificial intelligence, exhibit a continuous presence throughout project phases. Project governance becomes centralized around a limited number of actors and themes, constraining cognitive diversity and knowledge recombination. In addition, the study identifies a reconfiguration of the state’s role, with universities and hybrid organizations assuming greater operational responsibility.

Originality/value

This study offers an innovative perspective by reframing public health crises as mechanisms of institutional strengthening, integrating network analysis, R&D&I governance and mission-oriented innovation policies, with particular attention to the challenges and specificities of the Global South.

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