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Purpose

This study aims to analyze how economic policy uncertainty (EPU) influences the economic and financial performance of small and medium-sized enterprises (SMEs) located in a university environment.

Design/methodology/approach

To achieve the proposed objective, a sample of 449 companies located in the university environment of the Rey Juan Carlos University of Madrid (Spain) was taken for the period 2012–2020. Given the temporal and cross-sectional nature of the data, the chosen methodology was panel data analysis.

Findings

The results show how EPU has a negative impact on the performance of these SMEs. However, firm size and age are not influential factors in the relationship between EPU and the performance of SMEs.

Practical implications

This evidence provides more knowledge to SMEs located near a university to make decisions under uncertainty. Fiscal and monetary authorities should be aware of the impact of EPU, not only economic but also social.

Originality/value

This research provides more knowledge on the impact of EPU on firm performance, focusing on a specific segment of SMEs, namely those located in a university environment.

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