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A meeting report on the Keystone Symposium “Systems Approach to Plant Biology”, Big Sky, Montana, 26‐31 January, 2001. This symposium, sponsored by several plant biotech companies, brought together both industrial and academic researchers to plot bolder strategies for high‐throughput plant biological research. Broad‐ranging discussions covered historical discoveries, recent developments and exciting new trends that are emerging in this highly dynamic field. Participants from around the world appeared to be energized by the exciting possibilities for determining and, ultimately, controlling metabolic pathways and processes while recognizing that there is still much to do in order to understand the biological systems of all known genes.

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