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The functionalities of tourist destinations as regional innovation systems (RIS) still show substantial deficits. Especially for destinations in developing countries (DC), this incurs a wicked problem when it comes to unfolding the potentials of tourism for social innovation and sustainable regional development. Determining factors for these weaknesses are manifold, complex, multi-causal and prone to inherent system-dynamics making it difficult for destination management organisations to proactively monitor and control them in the long term. Backed by empirical comparative findings from rural destinations in Azerbaijan and Ecuador, this chapter tracks down selected major drivers of this wicked problem both from a monocausal-linear and multi-causal-dynamic analytical perspective. As a primary outcome, a set of suitable indicators will be presented to serve as a monitoring framework for a social innovation governance of DC destinations.

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