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Purpose

The purpose of this paper is to investigate the analogy of the human immune system with the economic auction theory.

Design/methodology/approach

The paper develops an analogy of bio‐immune system with competitive bidding in auction, then develops a model of the situation and discusses its managerial implications.

Findings

The human immune system can be benchmarked to model decision making under competitive environment, such as biddings in auctions and obtains gainful insights.

Practical implications

Various engineering, management, social science, and defense and security‐related applications of the model are suggested.

Originality/value

The paper presents a novel and innovative model with tremendous potential for varied applications.

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