Oral cancers that frequently arise include those with squamous cell carcinoma (OSCC), which is a worldwide public health concern. Machine learning-based categorization is constrained by time, subjectivity, inconsistency, errors, and application, as well as by existing algorithms for segmentation, clustering, and methods, which have an influence on stability. This research presents an innovative approach for automated oral cancer detection using efficient deep-learning techniques employed to histopathological images. The proposed method focuses on detecting OSCC utilizing the oral cancer annotated dataset. In the preprocessing phase, a weighted median filter and contrast-limited adaptive histogram equalization are used to enrich picture quality by reducing noise and enhancing contrast. The segmentation phase utilizes the U-Net architecture, consisting of contracting and expansive paths with multilevel skip connections, to accurately segment the preprocessed images. The third phase employs an augmented convolutional neural network model, incorporating 22 layers, including convolutional, max-pooling, flattening, dense layers, and activation functions, to perform the classification. Evaluation of the suggested model is conducted based on various evaluation metrics, such as accuracy, intersection over union, and dice coefficient, demonstrating its potential as a reliable tool for automated monitoring for oral cancer and aiding in prevention and treatment at an early stage planning.
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3 April 2026
Research Article|
December 03 2025
Automated oral cancer detection with histopathological images using efficient deep-learning models
Ann Mathew;
Department of Electronics and Communication Engineering,
SRM Institute of Science and Technology
, Kattankulathur, India
; Department of Electronics and Communication Engineering, Vimal Jyothi Engineering College, Chemperi, IndiaCorresponding author Ann Mathew (annagnesmathew@gmail.com)
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Maria Jossy A
Maria Jossy A
Department of Electronics and Communication Engineering,
SRM Institute of Science and Technology
, Kattankulathur, India
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Corresponding author Ann Mathew (annagnesmathew@gmail.com)
Competing interests On behalf of all authors, the corresponding author states that they have no competing interest.
Publisher: Emerald Publishing
Received:
February 20 2024
Accepted:
October 01 2025
Online ISSN: 2045-9866
Print ISSN: 2045-9858
Funding
Funding Group:
- Funding Statement(s): No fund was received for this work.
© 2025 Emerald Publishing Limited
2025
Emerald Publishing Limited
Licensed re-use rights only
Bioinspired, Biomimetic and Nanobiomaterials (2026) 15 (1): 4–13.
Article history
Received:
February 20 2024
Accepted:
October 01 2025
Citation
Mathew A, Jossy A M (2026), "Automated oral cancer detection with histopathological images using efficient deep-learning models". Bioinspired, Biomimetic and Nanobiomaterials, Vol. 15 No. 1 pp. 4–13, doi: https://doi.org/10.1680/jbibn.24.00010
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