SENSITIVITY ANALYSIS OF PHARMACOKINETIC SYSTEMS Available to Purchase

The analyses of experimental results which are necessary in the determination of the structure and rate constants of pharmacokinetic systems are frequently subject to considerable errors. These errors, resulting from assay techniques and from physiological mechanisms within the test subject, make interpretation of results difficult. This may lead to problems in distinguishing between various feasible models and can result in a need to employ over‐simplified models for subsequent work. A technique is proposed which may help to reduce the effects of such errors. The technique is applied to simulations of experiments and results are presented which allow comparison of the accuracy of the parameter estimates with those obtained by methods which are more normally employed.