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This article concludes that dietary choline and tryptophan could influence motivational state. Investigates the link between diet and motivational state. In particular, examines how the neurotransmitter precursors choline and tryptophan are derived from the diet, how an increase in these precursors can enhance the production of the neurotransmitters acetylcholine (ACh) and serotonin (5‐HT) in the brain, and finally how the increase in these neurotransmitters can increase neuronal function and, as a result, brain activity. Increased synaptic release of both ACh and 5‐HT was found to be associated with increased brain activity. A new “neurotransmitter binding theory” is hypothesised, which is then used to associate increased brain activity with elevations in mood and an increased ability to concentrate, think and make rational decisions.

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