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This chapter seeks to explain the manufacturing industries that have gone a lot of transformation in recent years. The changes were brought as a result of implementation of Industry 4.0 technologies. The aim of this chapter is to study Smart Manufacturing (SM) and to implement Industry 4.0 in a Sustainable Supply Chain. The study is qualitative which employs secondary sources of data. The data of the study were sourced from relevant published articles from 2017 to 23. Also the data were analyzed using thematic analysis. The results of the study revealed that, artificial intelligence (AI) Models, Cloud Connection, Smart Product, standard communication, cyber-physical system (CPS), virtual system builder among others are the requirements for adopting SM. While Augmented Reality (AR), 3D Printing, Big Data Analytics, AI, Internet of Things (IoT), among others are the major 14.0 technologies that enable Smart Manufacturing System (SMS). However, security issues, system integration, interoperability, multilingualism, standard interface, data quality, privacy concern, investment concern are the major challenges of implementing SMS for sustainable supply chain. This study concluded that, implementing SM in sustainable supply chain have significantly improved company's productivity, innovation, efficiency, effectiveness, cost-effective manufacturing operations as well as sustainable management.

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