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This paper sets out the events that led to the development of the hypothesis that brains are sexed and that this, at least in part, underlies the sex differentiation that is observed across the range of occupations. It is also suggested that an individual's brainsex is a powerful organising influence on his or her pattern of abilities, emotional life, motives, and interests. It therefore follows that choice of occupation is an indicator of an individual's essential psychological character. The roll played by chance factors in the evolution of the ideas presented here is highlighted.

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